http://nnr.sagepub.com/content/27/6/483.abstract?etoc
Abstract
Background. Somatosensory stimulation in
the form of repetitive peripheral nerve stimulation (RPSS) is a
promising strategy to improve
motor function of the upper limb in chronic stroke.
Home-based RPSS may be an alternative to hospital-based RPSS. Objectives.
To investigate the feasibility and safety of an innovative program of
home-based RPSS combined with motor training and to
collect preliminary data on the efficacy of this
program to enhance hand motor function in patients in the chronic phase
after
stroke. Methods. Twenty patients were
randomized to either active or sham RPSS associated with daily motor
training performed at home over
4 consecutive weeks. All the patients were able to
perform tasks of the Jebsen–Taylor Test (JTT). The primary outcome
measures
were feasibility, evaluated by self-reported
compliance with the intervention, and safety (adverse events). Secondary
outcomes
comprised improvements in hand function in the JTT
after end of treatment and after a 4-month follow-up period. Results.
There were no relevant adverse events. Compliance with RPSS and motor
training was significantly greater in the active group
than in the sham group. Upper extremity performance
improved significantly more in the active group compared with the sham
group at the end of treatment. This difference
remained significant 4 months later, even when differences in compliance
with
motor training were considered. Conclusions.
Home-based active RPSS associated with motor training was feasible, was
safe, and led to long-lasting enhancement of paretic
arm performance in the chronic phase after stroke
for those who can perform the JTT. These results point to the need for
an
efficacy trial.
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