Deans' stroke musings: Low testosterone and the risk of dementia in elderly men

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, September 14, 2014

Low testosterone and the risk of dementia in elderly men

Something for your doctor to consider when trying to prevent your 33% dementia chance post-stroke from an Australian study.

Low testosterone and the risk of dementia in elderly men

In this study, the authors aim was to examine the association of plasma estradiol and testosterone with risk for dementia in elderly men. Low levels of testosterone are associated with a risk for dementia in elderly men. The association between low bio–T and dementia may be more relevant to men 80 years or older and men with a high level of education.
Methods

Within the population based Three-City study, including 3650 men age 65 years and older, a case–cohort design was set up after 4-years of follow-up.
Baseline plasma levels of total 17-β estradiol (Total-E2), total testosterone (total-T) and bioavailable testosterone (bio-T) were measured for all cases of incident dementia (n=105) and for a random sample of the cohort (n=413).
Cox regression models were used to estimate multivariate steroid sex hormone-associated hazard ratios (HR) and 95% confidence intervals of dementia.

Results

There was a reverse J-shaped relationship between total-T and risk for dementia (P=.007).
Compared with the median tertile, the HRs associated with total-T in the lower and upper tertile were increased (HR, 2.33; P=.026; HR, 1.9, P=.126; respectively).
Low bio-T was associated with a greater risk for dementia (HR for one standard deviation of decreasing log(bio-T), 1.29; 95% confidence interval, 1.03–1.62).
An interaction was found between bio-T and age (P<.0001), and bio-T and education (P=.044).
Risk for dementia associated with low bio-T was greater in older men (80 years or older) than in younger men (younger than 80 years; HR, 3.11; P=.011 vs. HR, 1.07, P=.715, respectively) and in men with high level of education compared with those with low level of education (HR, 2.32; P=.0002 vs. HR, 0.95; P=.790, respectively).
No significant association was found between Total-E2 and dementia.