Deans' stroke musings: Anti-inflammatory drugs and risk of Alzheimer's disease: An updated systematic review and meta-analysis

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, October 15, 2014

Anti-inflammatory drugs and risk of Alzheimer's disease: An updated systematic review and meta-analysis

I guess we still know nothing definite about this. Don't start NSAID use based on this.
http://www.mdlinx.com/internal-medicine/newsl-article.cfm/5566342/ZZF307965849E94474BB34FC062CEC0F93/?
In the past 20 years, substantial evidence from laboratory and epidemiologic studies has suggested that anti–inflammatory medications could defer or prevent the occurrence of Alzheimer's disease (AD). However, several studies do not corroborate these findings. In this systematic review and meta–analysis, researchers evaluated the association between anti–inflammatory drug use and the incidence of AD. They concluded that while observational studies support the use of NSAIDs for prevention of AD, a randomized controlled trial (RCT) did not. They argue that well–designed studies and innovative approaches are required to illuminate the exact relationship between NSAID use and AD risk, as well as the appropriate dosage and duration of use to maximize benefit and safety.
Methods

Pubmed, Embase, and Cochrane Library databases were searched up to March 2014.
Studies evaluating the association between use of anti–inflammatory drugs and AD risk were included.
Relative risks (RRs) with 95% confidence intervals (CIs) were meta–analyzed using random effects models, and were grouped by anti–inflammatory type and duration of drug use.

Results

In observational studies, use of non–steroidal anti–inflammatory drugs (NSAIDs) was significantly associated with a reduced risk of AD (RR, 0.72; 95% CI, 0.62–0.84) compared to no use of NSAIDs, especially in long–term users (RR, 0.36; 95% CI, 0.17–0.74); the risks of AD were also lower in both aspirin (RR, 0.77; 95% CI, 0.63–0.95) and non–aspirin NSAID users (RR, 0.65; 95% CI, 0.47–0.88) compared with nonusers; whereas the use of corticosteroids showed no significant association (RR, 0.62; 95% CI, 0.26–1.46).
In the single RCT, NSAID use showed no significant effect on AD risk among dementia–free individuals (P<0.05).