Coupling of neurogenesis and angiogenesis after ischemic stroke

You'll have to have your doctor get this and update your stroke protocols based upon this new knowledge.  YOU DID GET STROKE PROTOCOLS? DIDN'T YOU?
Coupling of neurogenesis and angiogenesis after ischemic stroke

• Linhui Ruan^{a, 1},
• Brian Wang^{b, c, 1},
• Qichuan ZhuGe^a,
• Kunlin Jin^{a, b, c, ,}

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doi:10.1016/j.brainres.2015.02.042

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highlights

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Stroke is a leading cause of mortality and severe long-term disability worldwide.

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Stroke-induced neurogenesis and angiogenesis are regulated by many factors.

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Stroke-induced neurogenesis and angiogenesis are highly dependent on each other.

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Abstract

Stroke is a leading cause of mortality and severe long-term disability worldwide. Development of effective treatment or new therapeutic strategies for ischemic stroke patients is therefore crucial. Ischemic stroke promotes neurogenesis by several growth factors including FGF-2, IGF-1, BDNF, VEGF and chemokines including SDF-1, MCP-1. Stroke-induced angiogenesis is similarly regulated by many factors most notably, eNOS and CSE, VEGF/VEGFR2, and Ang-1/Tie2. Important findings in the last decade have revealed that neurogenesis is not the stand-alone consideration in the fight for full functional recovery from stroke. Angiogenesis has been also shown to be critical in improving post-stroke neurological functional recovery. More than that, recent evidence has shown a highly possible interplay or dependence between stroke-induced neurogenesis and angiogenesis. Moving forward, elucidating the underlying mechanisms of this coupling between stroke-induced neurogenesis and angiogenesis will be of great importance, which will provide the basis for neurorestorative therapy.