Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, March 5, 2015

New analysis of spider venom reveals seven promising compounds with the potential to relieve chronic pain

Send your doctor after this to see if this could possibly relieve CPSP.
http://www.alphagalileo.org/ViewItem.aspx?ItemId=150284&CultureCode=en
New research shows that seven compounds of the countless found in spider venom block a key step in the body’s ability to pass pain signals to the brain. The hunt for a medicine based on just one of these compounds, which would open up a new class of potent painkillers, is now a step closer according to new research published in the British Journal of Pharmacology.
Pain that cannot be controlled can ruin people’s lives. One in five people worldwide currently suffer from chronic pain, and existing pain treatments often fail to provide relief. The economic burden is huge, with chronic pain in the USA alone estimated to cost around $600 billion a year, greater than the combined economic cost of cancer, diabetes and stroke.
People sense that part of their body is hurting when nerves from the affected area send signals to the brain through what is called the pain pathway. “A compound that blocks Nav1.7 channels is of particular interest for us. Previous research shows indifference to pain among people who lack Nav1.7 channels due to a naturally-occurring genetic mutation – so blocking these channels has the potential of turning off pain in people with normal pain pathways,” says research team leader Professor Glenn King from The University of Queensland’s Institute for Molecular Bioscience, Australia.
Part of the search for new medicines has focused on the world’s 45,000 species of spiders, many of which kill their prey with venoms that contain hundreds – or even thousands – of protein molecules. Some of these molecules block nerve activity. “A conservative estimate indicates that there are nine million spider-venom peptides, and only 0.01% of this vast pharmacological landscape has been explored so far,” says researcher Dr Julie Kaae Klint. The challenge was to build a research method that could search through this huge number of peptides, looking for the ones that could be useful.
Taking up this challenge, the research team built a system that could rapidly analyse the compounds in spider venoms. Using their novel approach, venoms from 206 species of spider were screened, revealing that 40% of the venoms contained at least one compound that blocked human Nav1.7 channels. Of the seven promising compounds identified, they discovered one that was particularly potent, and also had a chemical structure that suggested it would have high levels of chemical, thermal, and biological stability, which would be essential for administering a new medicine. Together these properties make it particularly exciting as a potential painkiller.
“Untapping this natural source of new medicines brings a distinct hope of accelerating the development of a new class of painkillers that can help people who suffer from chronic pain that cannot be treated with current treatment options,” says Dr Klint. The novel screening approach used to isolate the protein molecules from spider venoms could also be applied to other compounds, opening up hope more widely for new and better medicines.

No comments:

Post a Comment