This is in mice so your doctor will need to start up a clinical trial in humans on this. They will also need to account for the negative possibilities from anti-depressants. You do expect your doctor to know a definitive answer within the year?
DON'T YOU?
The neurogenesis trial;
Department of Neuroscience, Columbia University, New York, New York.
| Adult hippocampal neurogenesis is increased by antidepressants, and is required for some of their behavioral effects.
However, it remains unclear whether expanding the population of adult-born neurons is sufficient to affect anxiety and depression-related behavior.
Here, we use an inducible transgenic mouse model in which the pro-apoptotic gene Bax is deleted from neural stem cells and their progeny in the adult brain, and thereby increases adult neurogenesis.
We find no effects on baseline anxiety and depression-related behavior; however, we find that increasing adult neurogenesis is sufficient to reduce anxiety and depression-related behaviors in mice treated chronically with corticosterone, a mouse model of stress.
Thus, neurogenesis differentially affects behavior under baseline conditions and in a model of chronic stress.
Moreover, we find no effect of increased adult hippocampal neurogenesis on HPA axis regulation, either at baseline or following chronic corticosterone administration, suggesting that increasing adult hippocampal neurogenesis can affect anxiety and depression-related behavior through a mechanism independent of the HPA axis.
The use of future techniques to specifically inhibit BAX in the hippocampus could be used to augment adult neurogenesis,
and may therefore represent a novel strategy to promote
antidepressant-like behavioral effects.Neuropsychopharmacology accepted
article preview online, 02 April 2015. doi:10.1038/npp.2015.85.
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