Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, August 1, 2015

Effect of Antibiotic Class on Stroke Outcome

In rats but it probably does mean that if you get an infection post-stroke you'll have to direct your doctor to give you the correct antibiotic. Once again, I bet this will not be followed up in human testing for 50 years because we have NO one running a stroke strategy. No one seems to give a shit about the trillions upon trillions of neurons dying every single minute worldwide.  We're flushing vast amounts of intelligence down the tube because the intelligence in our stroke associations is non-existent. 
http://www.ncbi.nlm.nih.gov/pubmed/26138122

Abstract

BACKGROUND AND PURPOSE:

Infections are common after stroke and associated with worse outcome. Clinical trials evaluating the benefit of prophylactic antibiotics have produced mixed results. This study explores the possibility that antibiotics of different classes may differentially affect stroke outcome.

METHODS:

Lewis rats were subjected to transient cerebral ischemia (2 hours) and survived for 1 month. The day after stroke they were randomized to therapy with ceftiofur (a β-lactam antibiotic), enrofloxacin (a fluoroquinolone antibiotic), or vehicle (as controls) and underwent the equivalent of 7 days of treatment. Behavioral tests were performed weekly until euthanization. In a subset of animals, histology was done.

RESULTS:

There were no differences in outcomes at 24 hours or 1 week after stroke among the different groups. At 1 month after stroke, however, performance on the rotarod was worse in enrofloxacin-treated animals when compared with control animals.

CONCLUSIONS:

Independent of infection, the antibiotic enrofloxacin was associated with worse stroke outcome. These data echo the clinical observations to date and suggest that the secondary effects of antibiotics on stroke outcome should be considered when treating infection in subjects with stroke. The mechanism by which this antibiotic affects outcome needs to be elucidated.

1 comment:

  1. My stroke was caused by a rare bacterial infection called Whipple Disease. It took 2 weeks in the hospital after the stroke and about 60 doctors to diagnose and start 28 days of IV brain membrane penetrating antibiotics to kill the bacteria and stop the death cascade of neurons, but not before it killed a 2.4 cm x 4.0 cm area of the upper motor cortex leaving me w/ 100% hemiparesis of my non-dominant left side. No one explained that aspect to me. I figured it out after I found your blog. Thank you for doing this.

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