Deans' stroke musings: Chemical Test Quickly Finds Cognitive Damage in Stroke Patients

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, November 14, 2015

Chemical Test Quickly Finds Cognitive Damage in Stroke Patients

Knowing this really does no fucking good because there are NO stroke protocols to alleviate cognitive problems. At least not publicly available which is what our fucking failures of stroke associations should have available for us.

http://www.scientificamerican.com/article/chemical-test-quickly-finds-cognitive-damage-in-stroke-patients/?
A stroke happens when blood flow to the brain is interrupted and brain cells starve of oxygen. Aftereffects include muscle weakness and altered senses. In many cases, strokes also affect the way a patient thinks or processes information.
Quickly identifying the effects of a stroke helps doctors to tailor rehabilitation programs to the needs of a patient. Currently, structural neuroimaging and neuropsychological tests assess cognitive damage, but these take time and require the patient to be involved and compliant.
Now, a team led by Weizhong Wang and Xiaoying Bi from the Second Military Medical University in Shanghai has analysed metabolic changes following a stroke. The researchers were particularly interested in identifying changes related to post-stroke cognitive impairment. Bi explains that these changes may be ‘caused by inflammation, neurotoxicity or oxidative stress’ because of the stroke.
The team used paired ultra-high performance liquid chromatography and Q-TOF mass spectrometry to study serum samples from a control group, a post-stroke cognitively impaired group and a post-stroke non-cognitively impaired group of patients. Multivariate data analysis of the data set highlighted the different metabolic profiles of the groups and identified a wide range of metabolic changes.

To create a practical test, the team then used a regression model to pare down the metabolites to three that were simple to check for: glutamine—an amino acid; kynurenine—a metabolite of tryptophan; and lysoPC(18:2)—a lysophospholipid. These biomarkers can rapidly identify post-stroke cognitive impairment without actively involving the patient in the testing.
Peng Song, a specialist in neuro-analytical chemistry, from the Eastman Chemical Company in the US says the research signals the coming age of clinical metabolomics. ‘The finding paves the way for a better understanding of the molecular mechanisms and eventually, more effective treatment,’ he adds.
This article is reproduced with permission from Chemistry World. The article was first published on November 2, 2015.