Deans' stroke musings: Feasibility of progesterone treatment for ischaemic stroke

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, November 11, 2015

Feasibility of progesterone treatment for ischaemic stroke

Since I have no idea what the failed trials looked like I can't tell if they were run properly or came to the right conclusions. Our fucking failures of stroke associations should know this and be following up with research for stroke.
http://jcb.sagepub.com/content/early/2015/11/10/0271678X15616782.abstract?&

¹Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, UK
²Stroke, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK

Claire L Gibson, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 9HN, UK. Email: cg95@le.ac.uk

Abstract

Two multi-centre phase III clinical trials examining the protective potential of progesterone following traumatic brain injury have recently failed to demonstrate any improvement in outcome. Thus, it is timely to consider how this impacts on the translational potential of progesterone treatment for ischaemic stroke. A wealth of experimental evidence supports the neuroprotective properties of progesterone, and associated metabolites, following various types of central nervous system injury. In particular, for ischaemic stroke, studies have also begun to reveal possible mechanisms of such neuroprotection. However, the results in traumatic brain injury now question whether further clinical development of progesterone for ischaemic stroke is relevant.